Welcome to the Mangalam Lab

The major goal of my research is to develop better treatment options to cure multiple sclerosis (MS). To achieve this goal, my research program focuses on three major interconnected themes:

  1. To understand the role of gut microbiome and metabolome in the etiopathogenesis of MS;
  2. Test therapeutic efficacy of human gut derived bacteria as drug (BRUG) in animal models of MS; and
  3. Utilize transgenic mice expressing MS susceptible and resistant HLA class II molecules (HLA transgenic mice) to understand the mechanisms of disease pathogenesis.

Lab Members in the News

Rachel shaking hands and receiving an award from a presenter

Rachel Fitzjerrells Wins First Place in Oral Presentations at the Iowa Section of the AADOCR

Tuesday, March 19, 2024
Rachel Fitzjerrells, a Bioinformatics and Computational Biology PhD student in the Mangalam Lab, won the prestigious Max Smith Oral Presentation Award at the 71st Iowa Section AADOCR on February 13th, 2024.
Stephanie and Ashutosh in front of some colorful leaves

Stephanie Peterson successfully defends and publishes her Ph.D. Thesis

Tuesday, October 24, 2023
Stephanie Peterson successfully defended her PhD thesis in early October and completed the Immunology PhD program.
Peter Lehman and Dr. Mangalam

Peter Lehman successfully defends and publishes his M.S. Thesis

Friday, July 28, 2023
Peter Lehman successfully defended his M.S. thesis this past June and completed the Pathology M.S. program. Peter’s thesis is entitled Effect of Gut Microbiota Modulation During Early-life and Adulthood on Host Immunity. He performed his thesis work in the laboratory of Dr. Ashutosh Mangalam where he examined the effects of gut microbiome disruption on immune function.

Lab Research in the News

Dr. Mangalam

Dr. Ashutosh Mangalam receives a new Merit Award from the Department of Veteran Affairs

Tuesday, October 24, 2023
Dr. Ashutosh Mangalam received a four-year VA Merit Award entitled “Role of HLA Class-II Polymorphism in the Regulation of Host-Microbiota Symbiosis”.
Dr. Mangalam

Dr. Ashutosh Mangalam Interviewed on the Importance of Microbiome in Health and Disease for “Health You” a Quarterly Health Publication of “The Gazette” Newspaper

Tuesday, August 15, 2023
Dr. Ashutosh Mangalam was interviewed on the significance of the microbiome in health and disease for “Health You” a quarterly health publication of the Cedar Rapids Gazette newspaper.
Dr. Mangalam

Dr. Ashutosh Mangalam receives a major gift from Ms. Margaret Heppelmann and Mr. Michael G. Wacek to study the role of natural versus synthetic progesterone in modulating immune responses

Monday, May 15, 2023
Autoimmune diseases affect millions of people in the United States. According to estimates from the American Autoimmune Related Diseases Association, there are over 50 million Americans living with autoimmune diseases, which translates to 1 in 5 people.