Multiple sclerosis (MS) is a chronic neuroinflammatory disease affecting nearly three million people worldwide. While the gut microbiome has been widely studied in MS, the role of the oral microbiome has remained largely unexplored. Two recent studies from Ashutosh Mangalam, PhD’s laboratory now provide converging evidence that oral microbial imbalance is closely linked to immune activation and metabolic disruption in people with relapsing-remitting MS (RRMS), highlighting oral health as an underappreciated contributor to MS pathobiology.

In this episode of the ECTRIMS Podcast, host Brett Drummond is joined by Mahesh Desai (Luxembourg Institute of Health) and Ashutosh Mangalam (University of Iowa), two internationally recognised leaders in microbiome and MS research, to explore how gut microbes influence disease susceptibility, progression, and immune regulation in MS.